There are several factors worsening the effects of the Great Resignation on clinical research. While the rates of resignation among healthcare workers are at their highest and trending upward, the need for participants in trials is also on the rise. This adds to the toll taken on research sites as more training and oversight is required for younger, less experienced employees. There are also limited opportunities for job growth and salary increases for CRAs, clinical research coordinators (CRCs), and project managers. And of course, a shortage of healthcare workers and researchers in turn negatively affects the care that is provided to patients.